Not too hard.. definately something you could do in your driveway as long as you have a socket set.
The hardest part is going to be the nut at the bottom of the fender behind the wheels. Its probably the most rusted, and if the car has every been jacked up incorrectly you will notice it here.
Remove the headlamp. Refer to Headlamp Replacement in Lighting Systems.
Remove the hood panel. Refer to Hood Replacement .
Remove the wheelhouse panel. Refer to Wheelhouse Panel Replacement .
Remove the rocker panel molding. Refer to Molding Replacement - Rocker Panel in Exterior Trim.

Remove the bolts (3) retaining the fender (1) at the rocker panel.
From inside the wheel opening, remove the bolts (4) retaining the rear of the fender (1).
Remove the bolts retaining the fender (1) at the headlamp opening.
Remove the bolts (5) retaining the upper edge of the fender (1).
Remove the fender (1).